CD8A and neoplasm: The components of TME include myeloid cells such as glioma-associated macrophages (GAMs), bone-marrow-derived macrophages (BMDMs), myeloid-derived suppressor cells (MDSCs), tumor-associated neutrophils (TANs), but also resident microglia, dendritic cells, lymphoid cells including CD8+ cytotoxic T cells, T-helper cells, T-regulatory cells and non-immune cells such as neurons, astrocytes, pericytes and endothelial cells [18,19].