The CNI maps from pre-RT and 4 weeks post-RT are shown for two cases of wild-type IDH GBMs that had the highest volumes of pre-RT residual tumor (53.7 and 52.0 cc), as well as our mtIDH1-expressing case (85.1 cc pre-RT residual tumor), demonstrating the substantial differences in the observed sMRI response (Figure 5B). This evidence concerns the gene IDH1 and neoplasm.