PNPLA2 and obesity due to melanocortin 4 receptor deficiency: Polyphenolic compounds are reported to have anti-obesity activities that may derive from their effect on activation or inactivation of gene expression of transcription factors involved in lipid metabolism that include peroxisome proliferator-activated receptor γ (PPARγ), CCAAT-enhancer-binding proteins (C/EBPα), fatty acid synthase (FAS), adipose triglyceride lipase (ATGL), and forkhead transcription factor class O1 (FOXO1), Acetyl CoA carboxylase (ACC) [10].