Overexpression of KMD3C/JMJD1C promotes in vivo cell proliferation and tumorigenicity in a demethylase-independent manner, enhancing glycolytic and oxidative enzymes, which maintains leukemic cell bioenergetics and leads to severe acute myeloid leukemia (AML) characteristics [65]. The gene discussed is JMJD1C; the disease is acute myeloid leukemia.