PEComa is differentiated from ASPS due to its reactivity for HMB45 but recently aberrant expression of HMB45 was also reported in ASPS, though both tumors are TFE3 rearranged, diagnosis of ASPS was favored based on presence of PAS-D needle crystals in ASPS (21). This evidence concerns the gene PMEL and neoplasm with perivascular epithelioid cell differentiation.