Nine up-regulated (CD44, DRG1, BSG, NCL, CRKL, TP53, PAK4, NAMPT, ACTL6A) and thirteen down-regulated proteins (PRDX1, PEBP1, FLNA, EPS8, YWHAG, TRIM28, TLN1, IDH2, TRAP1, GLYR1, MCM7, LAD1, TJP2) were associated with CRC tumorigenesis (P<0.05). Here, PAK4 is linked to colorectal carcinoma.