A hallmark gene set enrichment analysis (GSEA) of the DEGs (Figure S6f, Supporting Information) revealed the targeted genes of two proto‐oncogenes, E2F (enrichment score [ES] = 0.66, p < 0.001) and MYC (ES = 0.59, p < 0.001), are significantly upregulated in the selected MCF7 cells, which further implied enhanced tumorigenesis ability of the mechanoresilient cancer cells.[33, 34]. This evidence concerns the gene MYC and cancer.