Human OPN has two well-known integrin-binding motifs, a typical RGD (Arg–Gly–Asp) motif and an SVVYGLR (Ser-Val-Val-Tyr-Gly-Leu-Arg) integrin-binding site, through which it binds integrin family such as αvβ3, playing key roles in many physiological and pathological progresses, including inflammation, cancer, COPD, asthma, and fibrosis [27–29]. This evidence concerns the gene SPP1 and asthma.