SPP1 and pulmonary fibrosis: In another study, treatment of mice with RMV-7, an αv antibody interrupts the binding of OPN to integrins, significantly suppressed the formation of bleomycin-induced lung fibrosis, and in vitro, RMV-7 significantly repressed recombinant OPN-enhanced migration, adhesion, and proliferation of NIH3T3 murine fibroblasts [33].