TLR7 and esophageal squamous cell carcinoma: Exosomal FMR1-AS1 secreted from esophageal carcinoma CSCs can activate TLR7-NFκB signaling and increase the expression level of c-Myc, which results in esophageal squamous cell carcinoma (ESCC) cell proliferation, anti-apoptosis, and invasion [50].