Exosomal FMR1-AS1 secreted from esophageal carcinoma CSCs can activate TLR7-NFκB signaling and increase the expression level of c-Myc, which results in esophageal squamous cell carcinoma (ESCC) cell proliferation, anti-apoptosis, and invasion [50]. The gene discussed is MYC; the disease is esophageal squamous cell carcinoma.