Unstimulated whole saliva (UWS) is a complex biologic fluid that expresses raised levels of proinflammatory cytokines such as interleukin 1 beta (IL-1β) under periodontal and peri-implant inflammatory conditions such as periodontitis and peri-implant mucositis and peri-implantitis, respectively [22, 23]. This evidence concerns the gene IL1B and periodontitis.