PDE5A and esophageal disorder: The results of subgroup analysis showed that using PDE-5 inhibitors in reducing the amplitude of esophageal contractions were significantly lower in healthy individuals (SMD − 2.50, 95% CI: -3.81 to -1.18) compared with those with esophageal motility disorders (SMD − 1.19, 95% CI: -1.84 to -0.55) (Supplementary material).