Bromocriptine had one of the top most negative NCSs, suggesting the greatest anti-relation to pre-cystic gene expression (Fig. 3C), had multiple targets upregulated in cystic data sets (P21 and P28) (Fig. 4D), and also targets Drd3, which was previously found as a potential target for restoring HDAC5 nuclear transport in ADPKD (Fig. 5E) (Paul et al. 2019). Here, HDAC5 is linked to autosomal dominant polycystic kidney disease.