Consistent with previous findings, we identified genes known to have a significant role in the pathogenesis of ADPKD including WNT7A, LCN2, and MMP7 (Additional files 4 and 5; Data files “deseq2_outputs”) (Li et al. 2018; Petra et al. 2022; Viau et al. 2010; Wilk et al. 2023; Zhou et al. 2017). This evidence concerns the gene LCN2 and autosomal dominant polycystic kidney disease.