Previous studies have investigated the loss‐of‐function of ZEB1 by Cas9‐mediated ZEB1 knockouts,[66, 67] shRNA,[68, 69] and siRNA[70] and by gene knockout studies in mice.[71] Whilst these reports also re‐enforced the key role of ZEB1 in remodeling cell adhesion, and inhibiting migration and cell growth in several cancers, these studies did not report epigenetic reprogramming. This evidence concerns the gene ZEB1 and cancer.