Additionally, gene expression profiling by qRT‐PCR on dCas9‐KRAB All gRNA‐edited tumors revealed up‐regulation of pro‐mesenchymal TFs SNAI2, ZEB2, and TWIST1 at day 32 which could explain why the edited tumors were increasing tumor growth after day 32 post‐implantation despite the stability of ZEB1 silencing induced by dCas9‐KRAB (Figure S7B, Supporting Information). This evidence concerns the gene TWIST1 and neoplasm.