TGFBR2 and Autoimmunity: Unlike deleting floxed Tgfbr2 alleles in developing thymocytes using a Cd4-Cre transgene, deleting floxed Tgfbr2 alleles in mature T cells in the periphery using a distal-Lck-Cre transgene does not lead to autoimmunity or lymphoproliferation under steady state [236].