Monogenetic loss-of-function mutation of an X-linked gene called Foxp3 (forkhead box p3) was found to be accountable for multifocal lymphoproliferation autoimmunity syndrome in scurfy mice and IPEX (immunodysregulation, polyendocrinopathy, and enteropathy, X-linked) human patients [94–97]. Here, FOXP3 is linked to Abnormal intestine morphology.