These effects involve Jak2/STAT3 pathway and SOCS3, and the bidirectional interplay with IL-6, functions that can contribute to the regulation of the production of pro-inflammatory cytokines (e.g., IL-2, TNF-alpha), in particular of those involving in type 2 and eosinophilic inflammation (e.g., IL-4, IL-5). The gene discussed is TNF; the disease is inflammatory response.