In this context, given the higher leptin levels in some chronic disorders (e.g., rheumatoid arthritis, systemic lupus erythematosus and psoriasis) [11] and in some acute inflammatory conditions during infection, among which the SARS-CoV-2 infection [22–24], the favorable effect of statins use also in both chronic [11, 44] and acute disorders can be hypothesized, as reported in recent studies including COVID-19 patients [45, 46]. Here, LEP is linked to systemic lupus erythematosus.