Noteworthy, the complement cascade, which is part of the innate immune system involved in alcoholic liver disease [62], was enriched for the SE events in ELOVL7, LINC00665, NSUN4, and SRRM2. We also found that epithelial-mesenchymal transition (EMT) was enriched for the SE events in ELOVL7, SRRM2 and TBC1D5 and was depleted for DRC1 and LINC00665 in GSEA. Here, NSUN4 is linked to alcoholic liver diseases.