In addition, G9-mediated H3K9 dimethylation (H3K9me2) silences SLC7A2 expression, and SLC7A2 absence mediates CXCL1 upregulation via the PI3K/Akt/NF-κB pathway, recruiting MDSCs and promoting HCC growth and metastasis [94]. Here, AKT1 is linked to hepatocellular carcinoma.