Although all mice developed obesity in response to HFD, mean body weight changes and the percentage of weight gain over 16 weeks were significantly higher in End.LepR-KO mice compared to age-matched End.LepR-WT controls, in both male (Fig. 2B,D) and female (Fig. 2C,E) mice. The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.