TP53 and thyroid gland carcinoma: The inclusive pathways were ordered according to the normalized enrichment score (NES) calculation and the top-ten most enriched KEGG-based annotations among these modules were constructed, meanwhile, mRNAs count as well as the − log10(P-value), namely their hypothesis testing parameters, were all displayed in Fig. 4, in which the thyroid cancer and p53 signaling pathway were significantly enriched with the maximum score values.