Accordingly, lower levels of DDR1, MFN2 and OPA1 and higher levels of pAMPK were detected in WM983B and A375M2 tumours, compared to WM983A and A375P tumours (Fig. 8a, b) as shown in vitro (Figs. 3c and 7a). The gene discussed is OPA1; the disease is neoplasm.