CXCL8 and periodontitis: Oral epithelial cells in periodontitis are the first to initiate the innate immune response by producing proinflammatory cytokines such as IL-1β, IL-6, TNF-α, and IL-8 (or CXCL8), a chemokine attractant for neutrophils.33 In vitro, they have been shown to produce receptor activator of nuclear factor kappa B ligand (RANKL) in the basal state at a level sufficient for osteoclastic differentiation and activation in a coculture system with murine bone marrow (BM) MP.34