CDK2AP1 and cancer: Recently, however, a study from our laboratory indicated that, in oral squamous cell carcinoma (OSCC), loss of DOC1 as an integral subunit of the NuRD chromatin remodeling complex, triggers the deregulation of a key functional hallmark associated to cancer progression and metastasis, namely epithelial-to-mesenchymal transition (EMT) and its reverse MET [7].