CDK2AP1 and neoplasm: In order to better characterize the inverse relationship between CDK2AP1 and miR-21-5p expression as predicted by the results thus far, we performed a multiplex immunofluorescence (IF) and in situ hybridization (ISH) analysis of tumor tissue microarrays (TMAs) encompassing a retrospective cohort of primary oral squamous cell carcinoma of the tongue from patients that received surgery as the primary form of treatment (Table 1).