Prostaglandin E synthase 3 (Ptges3/p23), S100a9 (MRP14), 15-Hydroxyprostaglandin dehydrogenase (Hpgd), prostaglandin reductase 2 (Ptgr2), IL enhancer-binding factor 2 (Ilf2), and IL enhancer-binding factor 3 (Ilf3), which promote inflammation and/or increase with inflammation19–24, were increased in the vehicle (NEC) group compared to the control group (Fig. 7). This evidence concerns the gene HPGD and necrotizing enterocolitis.