Hierarchical clustering analysis based on neuroendocrine markers [30] showed that 51 SCLC cell lines were separated into 3 clusters, and all 3 ecMYC-containing cell lines were partitioned into cluster C2 (Fig. 7A) with high expression of MYC (Fig. 7C) and NEUROD1 (Fig. 7D). This evidence concerns the gene MYC and small cell lung carcinoma.