Here, we have selected a cohort of MYC-R patients from a simultaneously open, prospective population-based registration cohort of R-CHOP-treated DLBCL patients (HOVON-900 cohort) as controls to compare with the long-term follow-up data of the R2CHOP interventional group (HOVON-130 trial [18]). This evidence concerns the gene MYC and diffuse large B-cell lymphoma.