CircARSP91 participates in tumor immune surveillance by elevating UL16-binding protein 1 (ULBP1) mRNA and protein expression to promote NK cell function and by elevating the NK-mediated immune response in HCC.308 The circ-0000977/miR-153/HIF1 axis suppresses NK cell death, which contributes to HIF1-mediated immunological escape of PCa cells.309 These results indicate the influence of noncoding RNA on the TME and the potential of targeting them to improve antitumor immunotherapy. Here, ULBP1 is linked to hepatocellular carcinoma.