ULBP1 and neoplasm: CircARSP91 participates in tumor immune surveillance by elevating UL16-binding protein 1 (ULBP1) mRNA and protein expression to promote NK cell function and by elevating the NK-mediated immune response in HCC.308 The circ-0000977/miR-153/HIF1 axis suppresses NK cell death, which contributes to HIF1-mediated immunological escape of PCa cells.309 These results indicate the influence of noncoding RNA on the TME and the potential of targeting them to improve antitumor immunotherapy.