By catalyzing H3K27me3 modification, enhancer of Zeste homolog 2 (EZH2) induces chromatin condensation, hence silencing specific genes epigenetically.202 Using differential expression analysis and a predictive model, Du et al. discovered that EZH2 expression in prostate cancer (PCa) is associated with DNA methylation alterations, TME, and immune-related genes. This evidence concerns the gene EZH2 and Familial prostate cancer.