This study shed new light on the relationship between FTO and macrophage polarization.333 In contrast to the positive roles played by m6A writers in macrophages, YTHDF2 knockdown in macrophages (RAW264.7 cells) enhanced the expression of LPS-induced inflammatory cytokines, such as IL-1β, IL-6, TNF-α, and IL-12, resulting in an increasingly severe inflammatory response.334 Wu and colleagues found that the m1A reader YTHDF3 was highly expressed in abdominal aortic aneurysm (AAA) and located in macrophages, as determined by immunofluorescence staining of the AAA adventitia. This evidence concerns the gene YTHDF2 and triple-A syndrome.