In addition, in HCC, NAT10 expression was considerably positively correlated with the immune infiltration of B cells, CD8+ T cells, CD4+ T cells, neutrophils, macrophages, DCs, endothelial cells, and fibroblasts, and strongly correlated with multiple immune-related marker gene sets.289 These findings suggest a potential regulatory function of ac4C in the tumor immune microenvironment, although ac4C mRNA alteration has been found to increase tumor cell proliferation and metastasis. This evidence concerns the gene CD8A and neoplasm.