Knockdown of lnc-CD56 lowers CD56 expression, suggesting that lnc-CD56 is a positive regulator of CD56 and is required for the development and various functions of NK cells.366 LncRNA GAS5 is downregulated in NK cells of liver cancer patients, although it is upregulated in activated NK cells relative to non-stimulated NK cells. The gene discussed is NCAM1; the disease is liver cancer.