The high-risk group was shown to have increased infiltration of numerous immune cell types, including B cells; macrophages; immature DCs (iDCs); plasmacytoid DCs (pDCs); CD8+ T cells; neutrophils, T-helper cells, such as Th1 and Th2 cells; T follicular helper (TFH) cells; TILs; and Tregs.279 Similarly, an association of m7G modification with the TME in ccRCC has also been explored, and the m7G signature was found to be critical in the development of the TME in ccRCC. This evidence concerns the gene CD8A and nonpapillary renal cell carcinoma.