ADAR and cancer: In line with this, cancers with higher IFN-stimulated gene (ISG) profiles were discovered to be especially sensitive to ADAR1 knockdown, providing a theoretical basis for the treatment of tumors based on ISG signatures.284Some cancer types that are resistant to ADAR1 targeting can be made responsive by activating IFN signaling.285 According to Ishizuka et al., tumors became very sensitive to immunotherapy and ICI resistance was overcome after the RNA editing enzyme ADAR1 was disabled.