Targeting the METTL1-m7G-SLUG/SNAIL axis may be beneficial for preventing HCC metastasis after IRFA.268 It was reported that METTL1-mediated tRNA m7G deposition regulates the PI3K/AKT/mTOR signaling pathway by modulating global mRNA translation. This evidence concerns the gene METTL1 and hepatocellular carcinoma.