Tumor microenvironmental FX suppression is critical for M2 macrophage polarization because it reduces macrophage ERK1/2 and AKT phosphorylation and activation.336 Paracrine activation of Wnt/β-catenin signaling in macrophages is achieved by LINC00662 through upregulation of WNT3A expression and secretion in HCC. The gene discussed is WNT3A; the disease is hepatocellular carcinoma.