EZH2 and Ewing sarcoma: As for histone methylation, treatment with an EZH2 inhibitor sensitizes Effective cytolysis of Ewing sarcoma cells by GD2-specific CAR-modified T cells.421 This strategy is expected to be administered clinically to enhance the efficacy of adoptively transferred GD2-redirected T cells against Ewing sarcoma, although in vivo validation is required.