NOP2 and cancer: The risk model was found to be closely correlated with the TME, indicating a potential role for the m5C-related lncRNA prognostic risk model in the targeted treatment and prognosis of PDAC.263 In another study, the immunotherapy data associated with the m5C modification in 33 cancers was analyzed and it was found that NOP2 was elevated in most cancers and was closely correlated with tumor cell infiltration and immunotherapy efficacy.