CD4 and neoplasm: In addition, in HCC, NAT10 expression was considerably positively correlated with the immune infiltration of B cells, CD8+ T cells, CD4+ T cells, neutrophils, macrophages, DCs, endothelial cells, and fibroblasts, and strongly correlated with multiple immune-related marker gene sets.289 These findings suggest a potential regulatory function of ac4C in the tumor immune microenvironment, although ac4C mRNA alteration has been found to increase tumor cell proliferation and metastasis.