WNT3A and neoplasm: High LINC00662 expression in HCC is associated with overactivated WNT3A, M2 macrophage polarization, and poor prognosis in HCC patients, according to additional clinical evidence.337 Targeting these lncRNAs in the TAMs or tumor cells could be a feasible antitumor therapeutic strategy because they together alter the functions of TAMs via many mechanisms and influence carcinogenesis and metastasis.