As a crucial component of tumor immune surveillance, NK cells are innate lymphoid immune cells with the capacity to specifically target and eradicate cancer cells.361,364 Song and colleagues reported that deletion of METTL3 in NK cells downregulated protein expression of SHP-2 in a manner mediated by m6A modification, thereby rendering NK cells hyporesponsive to IL-15 and leading to reduced NK cell infiltration and dysfunction. The gene discussed is METTL3; the disease is neoplasm.