CTLA4 and nonpapillary renal cell carcinoma: YTHDF2 expression was also found to correlate with the invasion of immune cells into LGG, as evidenced by the upregulation of PD1, TIM-3, CTLA4, and TAM gene markers.250 In ccRCC, YTHDF2 expression has been confirmed to be markedly correlated with the abundance of immune cells, including CD8+ T cells, CD4+ T cells, macrophages, neutrophils, B cells, and DCs, indicating that it has potential as an indicator of ccRCC immune cell infiltration.251