Adjusted for age, sex, BMI, alcohol use, cardiovascular disease, smoking status and diabetes, each doubling in serum CRP was associated with −0.14% difference in HADS-T (95% CI −0.64 to 0.37, p value: 0.599), 0.27% difference in HADS-D (95% CI −0.20 to 0.75; p value: 0.260) and −0.77% difference in HADS-A (95% CI −1.24 to −0.29; p value: 0.002) (Fig. 1). Here, CRP is linked to diabetes mellitus.