EGFR and Familial prostate cancer: Out of the 49 overlapping genes, many are important cancer genes or prostate cancer genes, such as TP53 (Jillson et al. 2021), CTNNB1 (Patel et al. 2020), EGFR (Nastały et al. 2020), etc. We calculated IRS for the 49 overlapping genes, 12 uniquely identified by MultiNEP and 6 by DiSNEP (Supplementary Table S4).