ERBB2 and breast carcinoma: Pretherapeutic staging is based on a multitude of triple assessments of palpable breast lumps, including clinical examinations, imaging, and laboratory techniques.9,10 Histologic diagnosis and pathologic evaluation of essential markers, such as hormone receptors (HRs) and human epidermal growth factor receptor 2 (HER2), are critical for breast cancer treatment.9,11