This is further supported by patients with ERS undergoing ablation being more likely to harbor an SCN5A variant.19 This suggests that overlapping genetic features may underlie a significant minority of J-wave syndromes, ultimately contributing to reduced conduction reserve within RV epicardium.55 Furthermore, previous studies have shown that NaV1.5 may also have a role in the maintenance of normal cardiac structural integrity. The gene discussed is SCN5A; the disease is amelogenesis imperfecta type 1G.