Currently the incidence of ICI-related pancreatitis is low: 0.9–3% for anti-CTLA-4, 0.5–1.6% for anti-PD-1 and 1.2–2.1% for anti-CTLA-4 and anti-PD-1 combined.2 An elevated lipase has been reported in 2.3% of the patients receiving anti-PD1 or anti-PDL-1, though only 14% of them developed clinical or radiologic signs of real pancreatitis.3 Like autoimmune pancreatitis, ICI-related pancreatitis is considered a T-cell-mediated process. Here, CD274 is linked to pancreatitis.