Initially discovered in 1995 for its ability to specifically bind with the src homology 2 domain of p56lck, regulated by phosphorylation of Ser-59 in a phosphotyrosine-independent way, p62 has since been implicated in the pathogenesis of cardiometabolic disease, neurodegenerative disease, malignant tumors, and infectious diseases (Park et al., 1995; Seto et al., 2013; Jeong et al., 2019; Ma et al., 2019; Tang et al., 2021). This evidence concerns the gene SQSTM1 and infectious disease.