Extranuclear double-stranded (ds)DNA is an indicator of cellular damage or pathogen infection, and triggers a robust inflammatory response driven by the release of pro-inflammatory cytokines following the activation of the DNA sensors absent in melanoma 2 (AIM2), cyclic GMP-AMP synthase (cGAS), and toll-like receptor 9 (TLR9).2 Here, TLR9 is linked to infection.