IPMK and colorectal cancer: To investigate a potential role for IPMK in recovery from chemotherapy-induced acute intestinal injury, we treated IpmkF/F and IpmkΔIEC mice with a single dose of CPT-11 (irinotecan) (250 mg/kg), an agent currently being explored as a treatment for colorectal cancer (Figure 5A) and analyzed intestinal tissue 4 days later.