For example, various mechanisms of flavonol action on the androgen receptor (AR)-mediated signaling cascades have been proposed for their chemopreventive action in castrate-resistant prostate cancer [14], and quercetin has undisputed endothelium-independent vasodilator actions, prevents endothelial dysfunction, and prevents myocardial ischemic injury [116] and it is well recognized for its antioxidant function, and it inhibits the action of a large variety of enzymes. Here, AR is linked to endothelial dysfunction.