MTOR and neoplasm: Fisetin also induces apoptosis in several human laryngeal cancer cell lines (TU212, M2e, and Hep-2) via inhibiting tumor cell proliferation, inducing apoptosis and autophagy regulated by ERK1/2 and AKT/nuclear factor-kappa B (NF-κB)/mammalian target of rapamycin (mTOR) signaling pathways, with an IC50 of 10 μM [180].