Here, the analysis of snRNA-seq and ST showed that AVPR1A and OXTR were highly expressed in the pseudocapsule while down-regulated in the leiomyoma and that the pseudocapsule was filled with blood vessels, which explained why pituitrin take effects and indicated the optimal injection site should be located at the junction between pseudocapsule and leiomyoma. The gene discussed is OXTR; the disease is leiomyoma.