Bubble plot further showed fibroblasts interacted with other three cells (smooth muscle cells, endothelial cells and pericytes) mainly through IGF1-IGF1R (Figure 6C), indicating that fibroblast-secreted IGF1 might play an important role in the progression of uterine leiomyoma of patient 1. The gene discussed is IGF1; the disease is Uterine leiomyoma.