The single-cell transcriptomics showed that the expression level of prostaglandin E receptor 3 (PTGER3), one of top DEGs, was relatively high in smooth muscle cells and pericytes of surrounding pseudocapsule while was significantly down-regulated in the leiomyoma tissue in P1-SC and P2-SC (Figure 7A, B, F, G), which was further validated by spatially resolved analysis in both P1-ST and P2-ST (Figure 7C, H). Here, PTGER3 is linked to leiomyoma.