AKT1 and Hepatic fibrosis: Once activated by the chemokine ligand CCL2, CCR2 can stimulate multiple downstream signaling pathways in cancers, including the PI3K-Akt, RAC-GTPase, and PKC signaling pathways.39 However, the downstream signaling pathways and profibrotic genes activated by CCR2 in the context of liver fibrosis have not been fully explored.