CCR2 and Hepatic fibrosis: Consistently, our previous study explored whether LSEC-mediated aberrant angiocrine signals can recruit CCR2+ MDM accumulation in CCl4-induced liver fibrosis.12 In addition, CCR2 is also expressed in T/NK cells and neutrophils, and neutrophils also lead to CCR2-mediated macrophage infiltration and HSC activation37, 38.