Single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing indicate that CVC reduces liver fibrosis by inhibiting hepatic accumulation of inflammatory fascin actin-bundling protein 1 (FSCN1)+ macrophages and HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 (HERC6)+ neutrophils. Here, HERC6 is linked to Hepatic fibrosis.