CD4 and systemic lupus erythematosus: Up-regulation of miR-29b and miR-126 in CD4+ T cells also appeared to play an important role in SLE pathogenesis by suppressing DNMT1 and inducing hypomethylation, thereby enhancing expression of particular genes such as CD70 and CD11a that contributes to the autoreactive status of T cells 60, 61.