Meanwhile, regarding the more recently recognized Th17/Treg balance axis, it has been reported that T-helper-cells in lupus patients show skewing towards Th17 cells, as distinct cytokine profiles were observed: decreased IFN-γ, TGF-β and increased IL-17, each distinct cytokines of Th1 cells, Treg cells, and Th17 cells, respectively 51. The gene discussed is IL17A; the disease is systemic lupus erythematosus.