It was found that thymic stromal lymphopoietin (TSLP) secreted by tumor cells downregulated the expression of CXCR4 and VLA4 in B-cell precursors, enhanced their mobility, enabled them to migrate out of bone marrow, and induced the transformation of B-cell precursors into Bregs to promote tumor metastasis 77. The gene discussed is CXCR4; the disease is neoplasm.