We determined the expression of Zyxin in the skin tissues from SSc (n = 19) and keloid (n = 21) patients and normal samples (n = 21) and found a significant up-regulation of Zyxin in both SSc (2.32 ± 0.24 vs 1.11 ± 0.11, P < 0.01) (Figure 1D) and keloid patients (2.58 ± 0.32 vs 1.10 ± 0.12, P < 0.01) (Figure 1E). This evidence concerns the gene ZYX and systemic sclerosis.