Other studies have also shown Lurasidone, SAHA (HDAC inhibitor) 45,46, doxazosin (Classic Alpha 1-Adrenoceptor Antagonist inhibitor) 47, 3-methyladenine (3-MA, VPS34 inhibitor) 48 provoked autophagy to reverse osimertinib resistance of NSCLC. This evidence concerns the gene PIK3C3 and non-small cell lung carcinoma.