IFNA1 and neoplasm: Based on the above suggestive results that type I and II IFN signaling, essential drivers of anti-tumor immunity, were upregulated and might have a vital role in APOBEC mutagenesis mediated immune activation, we measured the expression of IFN-stimulated genes (ISGs) in different A3A level groups and found that most of ISGs were overexpressed in patients with high A3A levels (Figure 6A).