Furthermore, we found that miR-483-5p was enriched in AD-B-EVs and AD-P-EVs, and also demonstrated that it mediated the anti-osteogenic, pro-adipogenic, and pro-osteoporotic effects of AD-B-EVs associated with the inhibition of Igf2. Our study elucidated the role of B-EVs as a mediator of neuronal control of bone metabolism during AD conditions by transferring miR-483-5p. Here, IGF2 is linked to Alzheimer disease.