Single-cell RNA sequencing data analysis of BM from patients with different primary tumors23 showed that metastatic tumor cells with high UBE2C expression levels (Supplementary Figure S5F) also presented high levels of MTOR1 (Supplementary Figure S5G), with a positive correlation between the mRNA levels of both genes (Supplementary Figure S5H). This evidence concerns the gene UBE2C and metastatic neoplasm.