One possible explanation for the increased colonization of the leptomeninges, particularly in the spinal cord, in a poor microenvironment such as the cerebrospinal fluid (CSF), is that cancer cells with high levels of UBE2C have higher glycolytic activity, further promoting their migration and invasion abilities even in such environmental conditions.37,38 In fact, a metabolic diagnostic tool based on nuclear magnetic resonance (NMR) analysis of patients with leptomeningeal carcinomatosis showed increased lactate levels, a product of glycolysis.39 The gene discussed is UBE2C; the disease is cancer.