UBE2C has been described as a promoter of migration and invasion of tumor cells in endometrial cancer models, inducing epithelial to mesenchymal transition (EMT), via downregulation of p53 levels.34 Similar effects were also observed in gastric35 and hepatocellular cancers.36 We observed that orthotopic mouse models injected with cancer cells overexpressing UBE2C developed a more aggressive disease phenotype, with leptomeningeal dissemination in the brain and spinal cord. This evidence concerns the gene TP53 and hepatocellular carcinoma.