NR4A2 and Parkinson disease: A PD therapeutic target of interest for over 25 years is the nuclear receptor-related 1 protein (Nurr1) (Zetterstrom et al., 1996, Lin et al., 2012, Jeon et al., 2020), which is a transcriptional cofactor that upregulates the expression of genes essential for dopamine neuron differentiation and survival (Le et al., 1999; Decressac et al., 2013).