1. Obstructive airway disease (+3) 2. Nasal polyps (+3) 3. Mononeuritis multiplex (+1) 4. Eosinophilia ≥1z109/liter (+5) 5. Extravascular eosinophilic-pre-dominant inflammation on biopsy (+2) 6. Positive test for cANCA or anti-PR3 (−3) 7. Hematuria (−1) A score of ≥6 is needed. This evidence concerns the gene PRTN3 and nasal cavity polyp.