Second, although EGPA and MPA are characterized by the same type of ANCA (anti-MPO), the diseases differ significantly in their clinical phenotype [e.g., renal involvement or diffuse alveolar hemorrhage (DAH) is much more frequent and more severe in MPA than in EGPA] (56). The gene discussed is MPO; the disease is eosinophilic granulomatosis with polyangiitis.