1. Positive results in 82% EGPA patients with sensitivity and specificity of 82 and 44%, respectively, pre-dominated in males and associated with skin involvement. 2. Most positive patients had a negative IFT for ANCA. 3. There was no association between the presence and levels of anti-alpha-enolase antibodies and EGPA activity. 4. None of the EGPA patients and controls was positive for anti-EPO. This evidence concerns the gene ENO1 and eosinophilic granulomatosis with polyangiitis.