In addition to adipocyte-derived factors, the upregulation of monocyte chemoattractant protein-1 (MCP-1), tumor interleukin-6 (IL-6), and necrosis factor-α (TNF-α) might also have a role in the development of insulin resistance and promote the pathophysiological link between metabolic dysfunction and cardiovascular disease [5]. The gene discussed is CCL2; the disease is Insulin resistance.