aPLs are a group of autoantibodies against a variety of negatively charged phospholipids, including lupus anticoagulant (LA), anticardiolipin antibodies (aCL), anti-β2 glycoprotein-I antibodies (anti-β2 GPI), anti-phosphatidylserine (aPS), anti-phosphatidylinositol (API), anti-phosphatidylethanolamine (APE) etc. (6, 7), A recent study proposed the inclusion of LA, aCL and anti-β2 GPI antibodies in the laboratory diagnosis of APS (8). The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.