CD8A and hantavirus infectious disease: Previous studies have shown that Hantavirus infection induces a strong cellular immune response in humans, including an increase in the number of activated CD8+ T cells, specifically CD8+ T cells invading the kidneys of infected persons, and the specific expression of memory CD8+ T cells, and the persistence of this response persists even after HTNV or PUUV infection has subsided (17, 21, 28).