Moreover, studies on the correlation between the accumulation of CD8+ T cells and some inflammatory biomarkers in the kidney and the outcome have confirmed that CD8+ T cells may be involved in the inflammatory response of HTNV in the kidney (11–15, 21, 28, 30), and for patients with severe kidney injury, the local titer of CD8+ T cells in the kidney is higher, which has also been confirmed in animal tests (30–32). This evidence concerns the gene CD8A and kidney injury.