ITGB2 and small cell lung carcinoma: Since EVs produced by ITGB2- or mutITGB2-transfected A549 cells were able to induce RAS/MAPK/ERK signaling and SLCL markers in hPCLS (Figure 7H), we decided to investigate the EVs produced by the SCLC cell line NCI-H196 either non-transfected or transfected with siCtrl or siITGB2 or treated with binase (Figure 8).