Remarkably, the effects induced by NCI-H196 EVs on hPCLS were counteracted by siITGB2 transfection or binase treatment of NCI-H196 cells prior EVs isolation (Figure 8B-D), suggesting both, ITGB2-LOF as well as binase treatment, for the development of therapies against SCLC. Here, ITGB2 is linked to small cell lung carcinoma.