HIF1A and small cell lung carcinoma: We further observed increased levels of key downstream genes of EGFR signaling, such as VIM, NFKB2 and HIF1A, in RNA-seq data from SCLC cell lines as compared to NSCLC cell lines (Figure S4C-D) 37, which were confirmed by qRT-PCR-based expression analysis in FFPE human lung tissue (Figure S4E).