In addition, we demonstrated that the EVs produced by a SCLC cell line induced in hPCLS both, non-canonical ITGB2-mediated activation of KRAS/MAPK/ERK signaling and SCLC proteins, supporting the hypothesis that the cargo of EVs may influence the gene expression signature of hPCLS (Figure 8D). Here, ITGB2 is linked to small cell lung carcinoma.