Moreover, EVs isolated from ITGB2- or mutITGB2-transfected A549 cells induced NKX2-1, EZH2, ASH-1 and MYCN in treated hPCLS, whereas TP53 levels were reduced, thereby mimicking gene expression patterns that are characteristic of SCLC 52, 53. Here, TP53 is linked to small cell lung carcinoma.