NKX2-1 and small cell lung carcinoma: Moreover, EVs isolated from ITGB2- or mutITGB2-transfected A549 cells induced NKX2-1, EZH2, ASH-1 and MYCN in treated hPCLS, whereas TP53 levels were reduced, thereby mimicking gene expression patterns that are characteristic of SCLC 52, 53.