Moreover, EVs produced by NCI-H196 cells induced EZH2, H3K27me3 (Histone 3 tri-methylated at lysine 27) and NKX2-1 in treated hPCLS, thereby mimicking gene expression patterns that are characteristic of SCLC 52, 53. The gene discussed is NKX2-1; the disease is small cell lung carcinoma.