Future work will determine whether a similar mechanism of N-glycosylation participates in switching the EGFR complex formation from ITGA2-ITGB6 to ITGA2-ITGB2 in the course of the histological transformation from NSCLC to SCLC observed upon acquired EGFR-TKIs resistance 65. This evidence concerns the gene ITGB6 and non-small cell lung carcinoma.