Comparing the enrichment of the genes grouped into the Kyoto Encyclopedia of Genes and Genomes (KEGG) category “SCLC” and the SCLC-ITGB2-sig (Figure S7), we observed ES of 0.52 (P = 0.37) and 0.52 (P = 0.36) for the KEGG-SCLC set in SCLC patients of C2 and C1, respectively, whereas the ES of the SCLC-ITGB2-sig significantly improved to 0.97 (P = 8 E-03) and 0.98 (P = 8 E-03) in SCLC patients of C2 and C1, respectively. Here, ITGB2 is linked to small cell lung carcinoma.